Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS30080 (hldA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS30080
NCBI Old Locus TagBURCENK562V_C5956
Name
hldA
Replicon ctg7180000002940C
Genomic location 300992 - 301984 (+ strand)

Cross-References

RefSeq WP_006486849.1
GI 493532869
EC Number 5.1.3.20
GI 493532869
NCBI Locus Tag BURCENK562V_RS30080
NCBI Old Locus Tag BURCENK562V_C5956
RefSeq WP_006486849.1

Product

Feature Type CDS
Coding Frame 1
Product Name
ADP-L-glycero-D-manno-heptose-6-epimerase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -2.16
Kyte-Doolittle Hydrophobicity Value -0.301
Molecular Weight (kDa) 37218.7
Isoelectric Point (pI) 6.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4EJ0 ISOMERASE 04/06/12 Crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase from Burkholderia thailandensis BURKHOLDERIA THAILANDENSIS 2.609 X-RAY DIFFRACTION 93.2

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000895 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: hldA

Human Homologs

References

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737