Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS30075 (hldD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS30075
NCBI Old Locus TagBURCENK562V_C5955
Name
hldD
Replicon ctg7180000002940C
Genomic location 300004 - 300918 (+ strand)
Partial sequence -> 3' end.

Cross-References

RefSeq WP_034178296.1
GI 736004378
GI 736004378
NCBI Locus Tag BURCENK562V_RS30075
NCBI Old Locus Tag BURCENK562V_C5955
RefSeq WP_034178296.1

Product

Feature Type CDS
Coding Frame 1
Product Name
heptose 1-phosphate adenyltransferase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -7.61
Kyte-Doolittle Hydrophobicity Value 0.089
Molecular Weight (kDa) 32712.3
Isoelectric Point (pI) 5.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4E84 TRANSFERASE 03/19/12 Crystal Structure of Burkholderia cenocepacia HldA BURKHOLDERIA CENOCEPACIA 2.6 X-RAY DIFFRACTION 99.7
4E8W Transferase/Transferase Inhibitor 03/20/12 Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor BURKHOLDERIA CENOCEPACIA 2.8654 X-RAY DIFFRACTION 99.7
4E8Y Transferase/Transferase Inhibitor 03/20/12 Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor BURKHOLDERIA CENOCEPACIA 2.6 X-RAY DIFFRACTION 99.7
4E8Z Transferase/Transferase Inhibitor 03/20/12 Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor BURKHOLDERIA CENOCEPACIA 3.05 X-RAY DIFFRACTION 99.7

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000894 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: hldD

Human Homologs

References

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737