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               BCAL0207               
Key to diagram


View in GBrowse: (?) 20 putative orthologs Acknowledgements for this annotation
Gene Information
Strain Burkholderia cenocepacia J2315 (Tax ID: 216591) Replicon Chromosome_1(3602 genes, 3870082 bp) [ RefSeq ]
Gene name hppD  Alternate Gene Names  
Locus tag BCAL0207 (View 1 update) GenBank Identifier (GI) 206558614 (Precomputed BLAST results at BLINK )
Genomic location 237203 - 236106 (-) Feature type CDS 
Burkholderia Ortholog Group Explanation of Orthologous Groups
BG000231 
Orthology uncertain because more than one top BLASTp hit was identified.
Product Information
Product Name 4-hydroxyphenylpyruvic acid dioxygenase HppD (Class 1  Explanation of Product Name Confidence)
Alternate Product Names
Subcellular localization
Cytoplasmic (Class 3Explanation of Localization Confidence)
Alternate Annotations and Cross-References
RefSeq YP_002229374.1
GI 206558614
GBrowse Click here for a GBrowse View of this and other annotations.
Gene Ontology (GO)
GO Accession GO Term Evidence
Molecular Function
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity IEA
Biological Process
GO:0006559 L-phenylalanine catabolic process IEA
GO:0006572 tyrosine catabolic process IEA
Cellular Component
Reactions
EC Number 1.13.11.27
COG Predictions
COG PredictionExplanation of COG predictions
COG Accession Description Category
COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]. Amino acid transport and metabolism / General function prediction only
TIGRFAM Prediction
TIGRFAM predictionExplanation of TIGRFAM predictions
Accession Name Function Significance Role Sub Role
TIGR01263 4HPPD 4-hydroxyphenylpyruvate dioxygenase 8.3e-178 Energy metabolism Amino acids and amines
Pathways
Pathways Explanation of Pathways Field
Name Database Xref
Ubiquinone and other terpenoid-quinone biosynthesis KEGG bcj00130 Computationally Generated
Tyrosine metabolism KEGG bcj00350 Computationally Generated
Phenylalanine metabolism KEGG bcj00360 Computationally Generated
Metabolic pathways KEGG bcj01100 Computationally Generated
Homology
BLINK Precomputed BLAST results at BLINK
Homologs Explanation of Homologs Field 63% identity to HppD[A. hydrophila]
57% idenity to HppD[P. fluorescens]
32% idenity to HppD[S. avermitilis]
Most Similar Human Homolog
ENSP00000289004, Percent Identity: 28.16%, E-Value: 5e-25, Ensembl Release: 56.
Structure Features
PFAM predictions Explanation of PFAM predictions
Accession Domain Start Stop E-value Release No.
PF00903 Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. 171 282 6e-09 23.0
 
Sequence data
Upstream 500 BP Region CGCCCGCGCGCGCCGACGTCTCGTCGACCCGGACCGGCGCGAGGCCGCCACGCTTTTCGAGCCGCACGCTCACGTACGCGAGCAGGTCGAGCCCGAGCTT CTGCGGATTCAGCAGTGCGACGTAGCCGGTGATCACGCCGATGTCCTCGAGCCGCCGGATCCGCCGCAGGCACGGGCTCGGCGACAGGTTCACGCGCTCG GCGATCTCCTGGTTCGACAGGCGCCCGTTCTCCTGAAGAATCGCGAGAATTCGCCGATCGATGGCATCCAATTCGGCTTGCGCCATCTTCTGCCCTCCGT TGATTATTTTGAGACTGGAAATTGCGCCATCGTAGGCGCGGGCGATCAAGTTCGCAAGTTTCCGCTCGCGGCCGCCCGCTACACTCTGTCGCATGTCTCG ACGCGCCGCACACGCTCATTGCGGAGGCGGCCGTCGACATCGAACCAGGCCGAGCAGGCGCACGCCGCCCCGGCCGATCGCCCCGCACAGGAGACACGAC

BLAST search against this genome or other genomes in database
Need more than 500 BP? Try our sequence retrieval tool or view intergenic regions in GBrowse.

DNA Sequence ATGCAGATCCCCACCTGGGACAACCCCGTCGGCACCGACGGCTTCGAATTCATCGAATACACGGCACCGGACCCGAAAGCGCTCGGACACCTGTTCGAAC GGATGGGTTTCACCGCGATCGCGCGCCATCGCCACAAGGACGTGACGGTGTACCGCCAGGGCGACATCAACTTCATCATCAACGCCGAACCCGATTCGTT CGCGCAACGCTTCGCGCGGCTGCACGGCCCGTCGATCTGCGCGATCGCGTTCCGCGTGCAGGACGCCGCGAAGGCGTACCAGCGTGCGCTGGAACTCGGC GCGTGGGGCTTCGACAACAAGACGGGCCCGATGGAGCTGAACATCCCGGCGATCAAGGGGATCGGCGATTCGCTGATCTATTTCGTCGACCGCTGGCGCG GCAAGAACGGCGCGCAGCCGGGCGCGATCGGCGACATCAGCATCTACGACGTCGACTTCGAGCCGATTCCCGGCGCGAACCCGAACCCGGTCGGGCACGG CCTCACCTACATCGACCACCTGACGCACAACGTGCATCGCGGCCGCATGCAGGAATGGGCCGAGTTCTACGAGCGCCTGTTCAACTTCCGCGAAGTGCGC TACTTCGACATCGAAGGCAAGGTGACCGGCGTGAAGTCGAAGGCGATGACGTCGCCGTGCGGCAAGATCCGCATCCCGATCAACGAGGAAGGCTCGGACA CGGCCGGCCAGATCCAGGAATACCTCGACGCGTATCACGGCGAAGGCATCCAGCACATCGCGCTCGGCGCGAGCGACATCTACCAGGCGGTCGACGGGCT GCGCAGCAAGGAAGTGAAGCTGCTCGACACGATCGACACGTATTACGAGCTGGTCGACCGCCGCGTGCCGAACCACGGCGAATCGCTGGCCGAGCTGAAG AAACGCAAGATCCTGATCGACGGCGCGCGCGACGACCTGCTGCTGCAGATCTTCACCGAGAACCAGATCGGGCCGATCTTCTTCGAGATCATCCAGCGCA AGGGCAACCAGGGCTTCGGCGAAGGCAACTTCAAGGCGCTGTTCGAATCGATCGAGCTCGACCAGATCCGCCGCGGCGTCGTGCAGGACAAGGCCTGA

BLAST search against this genome or other genomes in database


Downstream 500 BP region Click here to view the nucleotide sequence of the region 500 BP downstream of this gene.

Protein Sequence MQIPTWDNPVGTDGFEFIEYTAPDPKALGHLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYQRALELG AWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIPGANPNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVR YFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQEYLDAYHGEGIQHIALGASDIYQAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLAELK KRKILIDGARDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

BLAST search against this genome or other genomes in database
View precomputed BLAST results against all genomes at NCBI BLINK
References
PubMed Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate.
Keith KE, Killip L, He P, Moran GR, Valvano MA.
J Bacteriol. 2007 Dec;189(24):9057-65. Epub 2007 Oct 12.
PMID: 17933889
 
We thank Cystic Fibrosis Foundation Therapeutics, Inc. for critical funding support for the Burkholderia Genome Database.



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Burkholderia Genome Database Version 1.0