Strain |
Burkholderia glumae BGR1
GCF_000022645.2|latest |
Locus Tag |
bglu_2g06400
|
NCBI Locus Tag | BGLU_RS21055 |
Name |
toxA
Synonym: TRP-1 |
Replicon | chromosome 2 |
Genomic location | 769152 - 769889 (+ strand) |
Comment | Further details in Identification of Proteins Involved in Toxin Production by Pseudomonas glumae. published in Japanese Journal of Phytopathology 64(2):75-79,January 1998. |
Comment | Member of the toxoflavin biosynthesis gene cluster |
RefSeq | WP_012733471.1 |
GI | |
Entrez | 7904514 |
NCBI Locus Tag | BGLU_RS21055 |
NCBI Old Locus Tag | bglu_2g06400 |
RefSeq | WP_012733471.1,GeneID |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
methyltransferase ToxA
|
Synonyms |
putative ubiquinone/menaquinone biosynthesis methyltransferase |
Evidence for Translation | |
Charge (pH 7) | -5.89 |
Kyte-Doolittle Hydrophobicity Value | -0.269 |
Molecular Weight (kDa) | 27591.9 |
Isoelectric Point (pI) | 5.16 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
5JE0 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA with bound S-adenosylhomocysteine (SAH) and 1,6-didemethyltoxoflavin | BURKHOLDERIA GLUMAE | 1.552 | X-RAY DIFFRACTION | 100.0 |
5JE2 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA Y7F mutant with bound S-adenosylhomocysteine (SAH) | BURKHOLDERIA GLUMAE | 1.519 | X-RAY DIFFRACTION | 99.6 |
5JE3 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA Y7A mutant with bound S-adenosylhomocysteine (SAH) | BURKHOLDERIA GLUMAE | 1.792 | X-RAY DIFFRACTION | 99.6 |
5JE1 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA with bound S-adenosylhomocysteine (SAH) and toxoflavin | BURKHOLDERIA GLUMAE | 1.95 | X-RAY DIFFRACTION | 100.0 |
5JE4 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA Y7A mutant with bound S-adenosylhomocysteine (SAH) | BURKHOLDERIA GLUMAE | 1.932 | X-RAY DIFFRACTION | 99.6 |
5JDZ | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA with bound S-adenosylhomocysteine (SAH) | BURKHOLDERIA GLUMAE | 1.6 | X-RAY DIFFRACTION | 100.0 |
5JDY | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA Y7F mutant with bound S-adenosylhomocysteine (SAH) and toxoflavin | BURKHOLDERIA GLUMAE | 1.77 | X-RAY DIFFRACTION | 99.6 |
5JE5 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA with bound S-adenosylhomocysteine (SAH) and 1-demethyltoxoflavin | BURKHOLDERIA GLUMAE | 1.564 | X-RAY DIFFRACTION | 100.0 |
5JE6 | TRANSFERASE | 04/17/16 | Crystal structure of Burkholderia glumae ToxA | BURKHOLDERIA GLUMAE | 1.571 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 285 genera
|
Burkholderia Ortholog Group |
BG035431 (6 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: bglu_2g06400
Search term: toxA
Search term: methyltransferase ToxA
|
Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis.
Fenwick MK, Philmus B, Begley TP, Ealick SE
Biochemistry 2016 May 17;55(19):2748-59
PubMed ID: 27070241
|