Burkholderia pseudomallei K96243, BPSS1439 (bbfA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1439
Name
bbfA
Replicon chromosome 2
Genomic location 1960277 - 1964869 (+ strand)

Cross-References

RefSeq YP_111449.1
GI
Entrez 3095852
INSDC CAH38912.1
NCBI Locus Tag BPSS1439
RefSeq YP_111449.1,GeneID
UniParc UPI000043BCC5
UniProtKB Acc Q63KC3
UniProtKB ID Q63KC3_BURPS
UniRef100 UniRef100_Q63KC3
UniRef50 UniRef50_Q3JLD1
UniRef90 UniRef90_Q63KC3

Product

Feature Type CDS
Coding Frame 1
Product Name
BbfA
Product Name Confidence: Class 1
Synonyms membrane-anchored cell surface protein
Evidence for Translation
Charge (pH 7) 1.37
Kyte-Doolittle Hydrophobicity Value 0.123
Molecular Weight (kDa) 145459.4
Isoelectric Point (pI) 8.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes BbfA mutation attenuated for virulence in BALB/c mouse model of melioidosis.
Reference 25830295

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 74 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020907 (7 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1439
Search term: bbfA
Search term: BbfA

Human Homologs

References

Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.
Lazar Adler NR, Stevens MP, Dean RE, Saint RJ, Pankhania D, Prior JL, Atkins TP, Kessler B, Nithichanon A, Lertmemongkolchai G, Galyov EE
PLoS One 2015;10(4):e0121271
PubMed ID: 25830295
Identification of a predicted trimeric autotransporter adhesin required for biofilm formation of Burkholderia pseudomallei.
Lazar Adler NR, Dean RE, Saint RJ, Stevens MP, Prior JL, Atkins TP, Galyov EE
PLoS One 2013;8(11):e79461
PubMed ID: 24223950