Burkholderia pseudomallei K96243, BPSS1434 (bpaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1434
Name
bpaA
Replicon chromosome 2
Genomic location 1948688 - 1956592 (+ strand)

Cross-References

RefSeq YP_111446.1
GI
Entrez 3096314
INSDC CAH38909.1
NCBI Locus Tag BPSS1434
RefSeq YP_111446.1,GeneID
UniParc UPI000043BCC2
UniProtKB Acc Q63KC6
UniProtKB ID Q63KC6_BURPS
UniRef100 UniRef100_Q63KC6
UniRef50 UniRef50_Q3JLD6
UniRef90 UniRef90_Q63KC6

Product

Feature Type CDS
Coding Frame 1
Product Name
Burkholderia pseudomallei adhesion A, BpaA
Product Name Confidence: Class 1
Synonyms membrane-anchored cell surface protein
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724).
Charge (pH 7) -10.11
Kyte-Doolittle Hydrophobicity Value 0.167
Molecular Weight (kDa) 247086.4
Isoelectric Point (pI) 4.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes bpaA mutation attenuated for virulence in BALB/c mouse model of melioidosis.
Reference 25830295

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 102 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020903 (77 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1434
Search term: bpaA

Human Homologs

References

Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.
Lazar Adler NR, Stevens MP, Dean RE, Saint RJ, Pankhania D, Prior JL, Atkins TP, Kessler B, Nithichanon A, Lertmemongkolchai G, Galyov EE
PLoS One 2015;10(4):e0121271
PubMed ID: 25830295