Strain |
Burkholderia cenocepacia J2315
GCF_000009485.1|latest |
Locus Tag |
BCAS0225
|
NCBI Locus Tag | QU43_RS69805 |
Name |
shvR
|
Replicon | chromosome 3 |
Genomic location | 243574 - 244566 (+ strand) |
RefSeq | WP_006482230.1 |
GI | 197295074 |
Entrez | 6804596 |
GI | 197295074 |
INSDC | CAR57157.1 |
NCBI Locus Tag | QU43_RS69805 |
NCBI Old Locus Tag | BCAS0225 |
RefSeq | WP_006482230.1,GeneID |
UniParc | UPI00017BB251 |
UniProtKB Acc | B4EPZ1 |
UniProtKB ID | B4EPZ1_BURCJ |
UniRef100 | UniRef100_B4EPZ1 |
UniRef50 | UniRef50_B1KBK8 |
UniRef90 | UniRef90_B1KBK8 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
LysR family regulatory protein
|
Synonyms |
shiny variant regulator, ShvR |
Evidence for Translation | |
Charge (pH 7) | 2.49 |
Kyte-Doolittle Hydrophobicity Value | -0.062 |
Molecular Weight (kDa) | 36469.3 |
Isoelectric Point (pI) | 7.64 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | BGD |
Category | ShvR regulator |
Evidence |
ECO:0000250
sequence similarity evidence used in manual assertion
|
Host Organism | Medicago sativa |
Notes | shvR in K56-2 is avirulent in alfalfa seedling model of infection. |
Reference | 17967860 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 472 genera
|
Burkholderia Ortholog Group |
BG005276 (86 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BCAS0225
Search term: shvR
Search term: LysR family regulatory protein
|
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
BMC Genomics 2009 Sep 17;10:441
PubMed ID: 19761612
|
The Burkholderia cenocepacia LysR-type transcriptional regulator ShvR influences expression of quorum-sensing, protease, type II secretion, and afc genes.
O'Grady EP, Nguyen DT, Weisskopf L, Eberl L, Sokol PA
J Bacteriol 2011 Jan;193(1):163-76
PubMed ID: 20971902
|
A LysR-type transcriptional regulator in Burkholderia cenocepacia influences colony morphology and virulence.
Bernier SP, Nguyen DT, Sokol PA
Infect Immun 2008 Jan;76(1):38-47
PubMed ID: 17967860
|
The afc antifungal activity cluster, which is under tight regulatory control of ShvR, is essential for transition from intracellular persistence of Burkholderia cenocepacia to acute pro-inflammatory infection.
Gomes MC, Tasrini Y, Subramoni S, Agnoli K, Feliciano JR, Eberl L, Sokol P, O'Callaghan D, Vergunst AC
PLoS Pathog 2018 Dec;14(12):e1007473
PubMed ID: 30513124
|