Burkholderia cenocepacia J2315, BCAM2762 (cblB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM2762
NCBI Locus TagQU43_RS68270
Name
cblB
Replicon chromosome 2
Genomic location 3125742 - 3126524 (- strand)

Cross-References

RefSeq YP_002235363.1
GI 206564600
Entrez 6930407
GI 206564600
NCBI Locus Tag QU43_RS68270
NCBI Old Locus Tag BCAM2762
RefSeq YP_002235363.1
UniProtKB Acc B4ELG1
UniProtKB ID B4ELG1_BURCJ

Product

Feature Type CDS
Coding Frame 1
Product Name
giant cable pilus chaperone protein
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -0.87
Kyte-Doolittle Hydrophobicity Value -0.177
Molecular Weight (kDa) 27847.2
Isoelectric Point (pI) 6.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Fimbrial
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Cable pili
Evidence ECO:0000354
gene neighbors evidence used in manual assertion
Host Organism Homo sapiens
Notes Cable pili are necessary for inducing A549 transformed human epithelial lung cell death via apoptosis
Reference 17537663

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 18 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005918 (91 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2762
Search term: cblB

References

Comment in: Nat Med. 1995 Jul;1(7):626-7.
The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Nat Med. 1995 Jul;1(7):661-6.
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US.
Infect Immun. 2005 Sep;73(9):5426-37.
PubMed ID: 16113259
Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia.
Sajjan US(1), Xie H, Lefebre MD, Valvano MA, Forstner JF.
Microbiology. 2003 Apr;149(Pt 4):961-71.
PubMed ID: 12686638