Burkholderia cenocepacia J2315, BCAM2759 (cblD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM2759
NCBI Locus TagQU43_RS68255
Name
cblD
Replicon chromosome 2
Genomic location 3121211 - 3122374 (- strand)

Cross-References

RefSeq WP_006485017.1
GI 206564597
Entrez 6930412
GI 206564597
INSDC CAR56623.1
NCBI Locus Tag QU43_RS68255
NCBI Old Locus Tag BCAM2759
RefSeq WP_006485017.1,GeneID
UniParc UPI00000B35C3
UniProtKB Acc B4ELF8
UniProtKB ID B4ELF8_BURCJ
UniRef100 UniRef100_U1XZC1
UniRef50 UniRef50_Q8KQJ7
UniRef90 UniRef90_Q8KQJ7

Product

Feature Type CDS
Coding Frame 1
Product Name
putative minor pilin and initiator
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 5.27
Kyte-Doolittle Hydrophobicity Value -0.263
Molecular Weight (kDa) 41804.9
Isoelectric Point (pI) 8.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Fimbrial
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Extracellular Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Cable pili
Evidence ECO:0000354
gene neighbors evidence used in manual assertion
Host Organism Homo sapiens
Notes Cable pili are necessary for inducing A549 transformed human epithelial lung cell death via apoptosis
Reference 17537663

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005921 (94 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2759
Search term: cblD

References

Comment in: Nat Med. 1995 Jul;1(7):626-7.
The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Nat Med. 1995 Jul;1(7):661-6.
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US.
Infect Immun. 2005 Sep;73(9):5426-37.
PubMed ID: 16113259
Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia.
Sajjan US(1), Xie H, Lefebre MD, Valvano MA, Forstner JF.
Microbiology. 2003 Apr;149(Pt 4):961-71.
PubMed ID: 12686638