Burkholderia cenocepacia J2315, BCAM2757 (cblT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM2757
NCBI Locus TagQU43_RS68245
Name
cblT
Replicon chromosome 2
Genomic location 3116427 - 3118961 (+ strand)

Cross-References

RefSeq WP_006485030.1
GI 206564595
Entrez 6930411
GI 206564595
INSDC CAR56621.1
NCBI Locus Tag QU43_RS68245
NCBI Old Locus Tag BCAM2757
RefSeq WP_006485030.1,GeneID
UniParc UPI00003785A0
UniProtKB Acc B4ELF6
UniProtKB ID B4ELF6_BURCJ
UniRef100 UniRef100_Q6JE32
UniRef50 UniRef50_B2U868
UniRef90 UniRef90_Q6JE32

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component regulatory system sensor kinase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 2.69
Kyte-Doolittle Hydrophobicity Value -0.105
Molecular Weight (kDa) 91260.9
Isoelectric Point (pI) 7.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001514 (1762 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2757
Search term: cblT

References

Comment in: Nat Med. 1995 Jul;1(7):626-7.
The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Nat Med. 1995 Jul;1(7):661-6.
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US.
Infect Immun. 2005 Sep;73(9):5426-37.
PubMed ID: 16113259
Genetic characterization of a multicomponent signal transduction system controlling the expression of cable pili in Burkholderia cenocepacia.
Tomich M(1), Mohr CD.
J Bacteriol. 2004 Jun;186(12):3826-36.
PubMed ID: 15175296