Burkholderia cenocepacia J2315, BCAM2757 (cblT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2757
NCBI Locus TagQU43_RS68245
Name
cblT
Replicon chromosome 2
Genomic location 3116427 - 3118961 (+ strand)

Cross-References

RefSeq WP_006485030.1
GI 206564595
Entrez 6930411
GI 206564595
INSDC CAR56621.1
NCBI Locus Tag QU43_RS68245
NCBI Old Locus Tag BCAM2757
RefSeq WP_006485030.1,GeneID
UniParc UPI00003785A0
UniProtKB Acc B4ELF6
UniProtKB ID B4ELF6_BURCJ
UniRef100 UniRef100_Q6JE32
UniRef50 UniRef50_B2U868
UniRef90 UniRef90_Q6JE32

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component regulatory system sensor kinase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 2.69
Kyte-Doolittle Hydrophobicity Value -0.105
Molecular Weight (kDa) 91260.9
Isoelectric Point (pI) 7.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 620 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001514 (1708 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2757
Search term: cblT

Human Homologs

References

The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Sun L, Jiang RZ, Steinbach S, Holmes A, Campanelli C, Forstner J, Sajjan U, Tan Y, Riley M, Goldstein R
Nat Med 1995 Jul;1(7):661-6
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US
Infect Immun 2005 Sep;73(9):5426-37
PubMed ID: 16113259
Genetic characterization of a multicomponent signal transduction system controlling the expression of cable pili in Burkholderia cenocepacia.
Tomich M, Mohr CD
J Bacteriol 2004 Jun;186(12):3826-36
PubMed ID: 15175296