Burkholderia cenocepacia J2315, BCAM2756 (cblR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM2756
NCBI Locus TagQU43_RS68240
Name
cblR
Replicon chromosome 2
Genomic location 3115330 - 3116046 (- strand)

Cross-References

RefSeq WP_012493630.1
GI 206564594
Entrez 6930262
GI 206564594
INSDC CAR56620.1
NCBI Locus Tag QU43_RS68240
NCBI Old Locus Tag BCAM2756
RefSeq WP_012493630.1,GeneID
UniParc UPI00003785A1
UniProtKB Acc B4ELF5
UniProtKB ID B4ELF5_BURCJ
UniRef100 UniRef100_Q6JE31
UniRef50 UniRef50_Q6JE31
UniRef90 UniRef90_Q6JE31

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component regulatory system response regulator protein
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 0.62
Kyte-Doolittle Hydrophobicity Value -0.134
Molecular Weight (kDa) 25770.1
Isoelectric Point (pI) 7.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 466 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002626 (183 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2756
Search term: cblR

References

Comment in: Nat Med. 1995 Jul;1(7):626-7.
The emergence of a highly transmissible lineage of cbl+ Pseudomonas (Burkholderia) cepacia causing CF centre epidemics in North America and Britain.
Nat Med. 1995 Jul;1(7):661-6.
PubMed ID: 7585148
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103
Cable pili and the 22-kilodalton adhesin are required for Burkholderia cenocepacia binding to and transmigration across the squamous epithelium.
Urban TA, Goldberg JB, Forstner JF, Sajjan US.
Infect Immun. 2005 Sep;73(9):5426-37.
PubMed ID: 16113259
Genetic characterization of a multicomponent signal transduction system controlling the expression of cable pili in Burkholderia cenocepacia.
Tomich M(1), Mohr CD.
J Bacteriol. 2004 Jun;186(12):3826-36.
PubMed ID: 15175296