Burkholderia cenocepacia J2315, BCAM2738 (ispH)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2738
NCBI Locus Tag	QU43_RS68140
Name	ispH
Replicon	chromosome 2
Genomic location	3099666 - 3100607 (+ strand)

Cross-References

RefSeq	WP_006485062.1
GI	206564575
Entrez	6930245
GI	206564575
INSDC	CAR56601.1
NCBI Locus Tag	QU43_RS68140
NCBI Old Locus Tag	BCAM2738
RefSeq	WP_006485062.1,GeneID
UniParc	UPI00017BA359
UniProtKB Acc	B4ELD6
UniProtKB ID	B4ELD6_BURCJ
UniRef100	UniRef100_B4ELD6
UniRef50	UniRef50_B4ELD6
UniRef90	UniRef90_B4ELD6

Product

Feature Type	CDS
Coding Frame	1
Product Name	4-hydroxy-3-methylbut-2-enyl diphosphate reductase Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	-9.91
Kyte-Doolittle Hydrophobicity Value	-0.010
Molecular Weight (kDa)	33765.1
Isoelectric Point (pI)	5.10

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 514 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004335 (654 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2738 Search term: ispH Search term: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Human Homologs

References

A two-tier model of polymyxin B resistance in Burkholderia cenocepacia. Loutet SA, Mussen LE, Flannagan RS, Valvano MA Environ Microbiol Rep 2011 Apr;3(2):278-85 PubMed ID: 23761261