Burkholderia cenocepacia J2315, BCAM2626 (hmuR)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM2626
NCBI Locus Tag	QU43_RS67585
Name	hmuR Synonym: huvA
Replicon	chromosome 2
Genomic location	2974342 - 2976615 (+ strand)
Comment	Member of the hemin uptake (hmu) operon

Cross-References

RefSeq	WP_006489211.1
GI	206564464
Entrez	6930151
GI	206564464
INSDC	CAR56490.1
NCBI Locus Tag	QU43_RS67585
NCBI Old Locus Tag	BCAM2626
RefSeq	WP_006489211.1,GeneID
UniParc	UPI00017BA449
UniProtKB Acc	B4EKB1
UniProtKB ID	B4EKB1_BURCJ
UniRef100	UniRef100_A0A0D1C7C3
UniRef50	UniRef50_A3P230
UniRef90	UniRef90_G7H864

Product

Feature Type	CDS
Coding Frame	1
Product Name	TonB-dependent outer membrane heme receptor HmuR Product Name Confidence: Class 2
Synonyms	putative heme receptor protein
Evidence for Translation
Charge (pH 7)	7.06
Kyte-Doolittle Hydrophobicity Value	-0.338
Molecular Weight (kDa)	82162.9
Isoelectric Point (pI)	8.81

Subcellular localization

Individual Mappings	Localization Confidence PMID Outer Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 336 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004242 (596 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM2626 Search term: hmuR Search term: TonB-dependent outer membrane heme receptor HmuR

Human Homologs

References

The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616. Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M Appl Environ Microbiol 2017 Aug 15;83(16) PubMed ID: 28625994

Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis. Kvitko BH, Goodyear A, Propst KL, Dow SW, Schweizer HP PLoS Negl Trop Dis 2012;6(6):e1715 PubMed ID: 22745846