Burkholderia cenocepacia J2315, BCAM2552 (llpE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM2552
NCBI Locus TagQU43_RS67220
Name
llpE
Replicon chromosome 2
Genomic location 2897263 - 2898123 (- strand)

Cross-References

RefSeq WP_006484499.1
GI 206564393
Entrez 6930416
GI 206564393
INSDC CAR56418.1
NCBI Locus Tag QU43_RS67220
NCBI Old Locus Tag BCAM2552
RefSeq WP_006484499.1,GeneID
UniParc UPI00000BC148
UniProtKB Acc B4EJQ2
UniProtKB ID B4EJQ2_BURCJ
UniRef100 UniRef100_Q8VL16
UniRef50 UniRef50_Q3JHF7
UniRef90 UniRef90_A9AM27

Product

Feature Type CDS
Coding Frame 1
Product Name
LlpE
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -1.71
Kyte-Doolittle Hydrophobicity Value 0.091
Molecular Weight (kDa) 30714.7
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 347 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004188 (649 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2552
Search term: llpE
Search term: LlpE

Human Homologs

Ensembl 97, assembly GRCh38.p12
neutral cholesterol ester hydrolase 1 [Source:HGNC Symbol;Acc:HGNC:29260]
E-value: 1.0e-05
Percent Identity: 29.0
Ensembl 97, assembly GRCh38.p12
neutral cholesterol ester hydrolase 1 [Source:HGNC Symbol;Acc:HGNC:29260]
E-value: 1.0e-05
Percent Identity: 29.0

References

Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia.
Nair BM, Joachimiak LA, Chattopadhyay S, Montano I, Burns JL
FEMS Microbiol Lett 2005 Apr 15;245(2):337-44
PubMed ID: 15837391