Burkholderia cenocepacia J2315, BCAM2307 (zmpB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM2307
NCBI Locus TagQU43_RS65910
Name
zmpB
Replicon chromosome 2
Genomic location 2587413 - 2589125 (+ strand)

Cross-References

RefSeq WP_006483806.1
GI 206564143
Entrez 6929882
GI 206564143
INSDC CAR56166.1
NCBI Locus Tag QU43_RS65910
NCBI Old Locus Tag BCAM2307
RefSeq WP_006483806.1,GeneID
UniParc UPI00017BA06B
UniProtKB Acc B4EHF6
UniProtKB ID B4EHF6_BURCJ
UniRef100 UniRef100_B4EHF6
UniRef50 UniRef50_B4EHF6
UniRef90 UniRef90_B4EHF6

Product

Feature Type CDS
Coding Frame 1
Product Name
zinc metalloprotease ZmpB
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -4.72
Kyte-Doolittle Hydrophobicity Value -0.276
Molecular Weight (kDa) 60547.5
Isoelectric Point (pI) 6.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Western blot evidence used in manual assertion
Extracellular Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category ZmpB protease
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Rattus norvegicus
Notes zmpB mutant in K56-2 is attenuated for virulence in agar bead model of chronic lung infection
Reference 16790782

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 20 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004001 (576 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM2307
Search term: zmpB

References

Burkholderia cenocepacia type VI secretion system mediates escape of type II secreted proteins into the cytoplasm of infected macrophages.
Rosales-Reyes R, Aubert DF, Tolman JS, Amer AO, Valvano MA.
PLoS One. 2012;7(7):e41726.
PubMed ID: 22848580
Burkholderia cenocepacia ZmpB is a broad-specificity zinc metalloprotease involved in virulence.
Kooi C, Subsin B, Chen R, Pohorelic B, Sokol PA.
Infect Immun. 2006 Jul;74(7):4083-93.
PubMed ID: 16790782