Burkholderia cenocepacia J2315, BCAM1867 (mgtC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM1867
NCBI Locus TagQU43_RS63735
Name
mgtC
Replicon chromosome 2
Genomic location 2085986 - 2086693 (+ strand)

Cross-References

RefSeq WP_006483946.1
GI 206563715
Entrez 6929501
GI 206563715
INSDC CAR55725.1
NCBI Locus Tag QU43_RS63735
NCBI Old Locus Tag BCAM1867
RefSeq WP_006483946.1,GeneID
UniParc UPI000052DD8C
UniProtKB Acc B4EMC9
UniProtKB ID B4EMC9_BURCJ
UniRef100 UniRef100_A0A071M8X9
UniRef50 UniRef50_G8MNW9
UniRef90 UniRef90_A0A087NXB9

Product

Feature Type CDS
Coding Frame 1
Product Name
MgtC
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 2.59
Kyte-Doolittle Hydrophobicity Value 0.347
Molecular Weight (kDa) 24803.6
Isoelectric Point (pI) 8.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category MgtC
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Mus musculus
Notes mgtC mutant in K56-2 defective for survival within murine RAW 264.7 macrophages
Reference 16988222

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 317 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003717 (663 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1867
Search term: mgtC
Search term: MgtC

References

The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages.
Maloney KE, Valvano MA.
Infect Immun. 2006 Oct;74(10):5477-86.
PubMed ID: 16988222
The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages.
Maloney KE, Valvano MA.
Infect Immun. 2006 Oct;74(10):5477-86.
PubMed ID: 16988222