Burkholderia cenocepacia J2315, BCAM0265 (amiI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM0265
NCBI Locus TagQU43_RS55730
Name
amiI
Replicon chromosome 2
Genomic location 318540 - 319955 (+ strand)

Cross-References

RefSeq WP_006491536.1
GI 206562132
Entrez 6928056
GI 206562132
INSDC CAR54123.1
NCBI Locus Tag QU43_RS55730
NCBI Old Locus Tag BCAM0265
RefSeq WP_006491536.1,GeneID
UniParc UPI00017B9A55
UniProtKB Acc B4EI76
UniProtKB ID B4EI76_BURCJ
UniRef100 UniRef100_A0A0D1DLH2
UniRef50 UniRef50_I2IE92
UniRef90 UniRef90_B1K7W7

Product

Feature Type CDS
Coding Frame 1
Product Name
putative amidase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -5.89
Kyte-Doolittle Hydrophobicity Value 0.103
Molecular Weight (kDa) 49895.7
Isoelectric Point (pI) 6.00

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category amidase
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Rattus norvegicus
Notes amiI mutant in K56-2 has reduced rate of persistence in agar bead model of chronic lung infection
Reference 14977960

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 597 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002518 (1238 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0265
Search term: amiI
Search term: putative amidase

References

The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia.
Baldwin A, Sokol PA, Parkhill J, Mahenthiralingam E.
Infect Immun. 2004 Mar;72(3):1537-47.
PubMed ID: 14977960