Burkholderia cenocepacia J2315, BCAL3455 (lpxC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL3455
NCBI Locus TagQU43_RS53985
Name
lpxC
Replicon chromosome 1
Genomic location 3784254 - 3785171 (- strand)

Cross-References

RefSeq WP_006487145.1
GI 206561792
Entrez 6933225
GI 206561792
INSDC CAR53778.1
NCBI Locus Tag QU43_RS53985
NCBI Old Locus Tag BCAL3455
RefSeq WP_006487145.1,GeneID
UniParc UPI00017B9E43
UniProtKB Acc B4E5Y5
UniProtKB ID LPXC_BURCJ
UniRef100 UniRef100_B4E5Y5
UniRef50 UniRef50_Q6D0I9
UniRef90 UniRef90_Q2SZH6

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -5.10
Kyte-Doolittle Hydrophobicity Value -0.057
Molecular Weight (kDa) 33506.0
Isoelectric Point (pI) 5.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 387 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000455 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL3455
Search term: lpxC

Human Homologs

References

Complete structural characterization of the lipid A fraction of a clinical strain of B. cepacia genomovar I lipopolysaccharide.
Silipo A, Molinaro A, Cescutti P, Bedini E, Rizzo R, Parrilli M, Lanzetta R
Glycobiology 2005 May;15(5):561-70
PubMed ID: 15610978