Burkholderia cenocepacia J2315, BCAL2829 (htrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL2829
NCBI Locus TagQU43_RS50760
Name
htrA
Replicon chromosome 1
Genomic location 3106541 - 3108025 (- strand)

Cross-References

RefSeq WP_006490099.1
GI 206561166
Entrez 6932826
GI 206561166
INSDC CAR53129.1
NCBI Locus Tag QU43_RS50760
NCBI Old Locus Tag BCAL2829
RefSeq WP_006490099.1,GeneID
UniParc UPI00017B9987
UniProtKB Acc B4EA13
UniProtKB ID B4EA13_BURCJ
UniRef100 UniRef100_B4EA13
UniRef50 UniRef50_Q1LH84
UniRef90 UniRef90_B1YVV2

Product

Feature Type CDS
Coding Frame 1
Product Name
HtrA protease
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 2.20
Kyte-Doolittle Hydrophobicity Value -0.022
Molecular Weight (kDa) 50966.4
Isoelectric Point (pI) 8.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Periplasmic Class 1
Periplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Protease
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes htrA mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 17220310

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 614 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002475 (677 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2829
Search term: htrA
Search term: HtrA protease

Human Homologs

Ensembl 83, assembly GRCh38
HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406]
E-value: 2.7e-37
Percent Identity: 37.1

References

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.
Flannagan RS, Aubert D, Kooi C, Sokol PA, Valvano MA.
Infect Immun. 2007 Apr;75(4):1679-89.
PubMed ID: 17220310
Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.
Flannagan RS, Aubert D, Kooi C, Sokol PA, Valvano MA.
Infect Immun. 2007 Apr;75(4):1679-89.
PubMed ID: 17220310