Burkholderia cenocepacia J2315, BCAL2710 (ispH)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL2710
NCBI Locus Tag	QU43_RS50170
Name	ispH
Replicon	chromosome 1
Genomic location	2976649 - 2977629 (- strand)

Cross-References

RefSeq	WP_006488968.1
GI	206561049
Entrez	6932740
GI	206561049
INSDC	CAR53012.1
NCBI Locus Tag	QU43_RS50170
NCBI Old Locus Tag	BCAL2710
RefSeq	WP_006488968.1,GeneID
UniParc	UPI000052D6E7
UniProtKB Acc	B4E8Y4
UniProtKB ID	B4E8Y4_BURCJ
UniRef100	UniRef100_B1JXB0
UniRef50	UniRef50_A2W828
UniRef90	UniRef90_A2W828

Product

Feature Type	CDS
Coding Frame	1
Product Name	4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Synonyms
Evidence for Translation
Charge (pH 7)	-5.18
Kyte-Doolittle Hydrophobicity Value	-0.088
Molecular Weight (kDa)	35272.2
Isoelectric Point (pI)	5.90

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 515 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG002367 (654 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL2710 Search term: ispH Search term: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Human Homologs

References

A two-tier model of polymyxin B resistance in Burkholderia cenocepacia. Loutet SA, Mussen LE, Flannagan RS, Valvano MA Environ Microbiol Rep 2011 Apr;3(2):278-85 PubMed ID: 23761261