Burkholderia cenocepacia J2315, BCAL1931 (arnB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL1931
NCBI Locus TagQU43_RS46200
Name
arnB
Replicon chromosome 1
Genomic location 2130635 - 2131786 (+ strand)
CommentIn PMID:27597847: arnT, arnB, arnC, arnA1, arnA2, and BCAL1935 located in the arn gene cluster harbored significantly low frequencies of transposon insertions (TraDIS). They were therefore categorized as essential by the authors.

Cross-References

RefSeq WP_006482866.1
GI 206560295
Entrez 6932121
GI 206560295
INSDC CAR52232.1
NCBI Locus Tag QU43_RS46200
NCBI Old Locus Tag BCAL1931
RefSeq WP_006482866.1,GeneID
UniParc UPI00017B9220
UniProtKB Acc B4EB17
UniProtKB ID B4EB17_BURCJ
UniRef100 UniRef100_A0A0D1D6F0
UniRef50 UniRef50_B1XTN6
UniRef90 UniRef90_A0A063BGV1

Product

Feature Type CDS
Coding Frame 1
Product Name
putative UDP-4-amino-4-deoxy-l-arabinose--oxoglutarate aminotransferas
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -2.22
Kyte-Doolittle Hydrophobicity Value -0.027
Molecular Weight (kDa) 41849.5
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4LC3 TRANSFERASE 06/21/13 X-ray crystal structure of a putative UDP-4-amino-4-deoxy-l-arabinose--oxoglutarate aminotransferase from Burkholderia cenocepacia BURKHOLDERIA CENOCEPACIA 1.6 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 539 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001693 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1931
Search term: arnB

Human Homologs

References

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.
Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA
J Bacteriol 2007 May;189(9):3639-44
PubMed ID: 17337576
PubMed ID: 22742453
Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS.
Wong YC, Abd El Ghany M, Naeem R, Lee KW, Tan YC, Pain A, Nathan S
Front Microbiol 2016;7:1288
PubMed ID: 27597847