Burkholderia cenocepacia J2315, BCAL1699 (pvdA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL1699
NCBI Locus TagQU43_RS45015
Name
pvdA
Replicon chromosome 1
Genomic location 1871220 - 1872596 (+ strand)

Cross-References

RefSeq WP_006486049.1
GI 206560061
Entrez 6933908
GI 206560061
INSDC CAR51997.1
NCBI Locus Tag QU43_RS45015
NCBI Old Locus Tag BCAL1699
RefSeq WP_006486049.1,GeneID
UniParc UPI00017B9307
UniProtKB Acc B4E997
UniProtKB ID B4E997_BURCJ
UniRef100 UniRef100_A0A0D1D7U4
UniRef50 UniRef50_O51940
UniRef90 UniRef90_O51940

Product

Feature Type CDS
Coding Frame 1
Product Name
L-ornithine 5-monooxygenase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -3.52
Kyte-Doolittle Hydrophobicity Value -0.205
Molecular Weight (kDa) 50999.1
Isoelectric Point (pI) 6.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Siderophore biosynthesis and uptake (ornibactin)
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes BCAL1699 is ortholog of BURCENK562V_RS23390 mutant that is attenuated for virulence in rat chronic respiratory infection model
Reference 10456885

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 121 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001462 (642 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1699
Search term: pvdA

References

Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: characterization of pvdA, the gene encoding L-ornithine N(5)-oxygenase.
Sokol PA(1), Darling P, Woods DE, Mahenthiralingam E, Kooi C.
Infect Immun. 1999 Sep;67(9):4443-55.
PubMed ID: 10456885