Burkholderia cenocepacia J2315, BCAL0995 (acpP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL0995
NCBI Locus TagQU43_RS41540
Name
acpP
Replicon chromosome 1
Genomic location 1083131 - 1083370 (+ strand)

Cross-References

RefSeq WP_004197638.1
GI 206559388
Entrez 6933547
GI 206559388
NCBI Locus Tag QU43_RS41540
NCBI Old Locus Tag BCAL0995
RefSeq WP_004197638.1,GeneID
UniProtKB Acc B4EAI3
UniProtKB ID B4EAI3_BURCJ

Product

Feature Type CDS
Coding Frame 1
Product Name
acyl carrier protein
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -12.01
Kyte-Doolittle Hydrophobicity Value -0.254
Molecular Weight (kDa) 8711.7
Isoelectric Point (pI) 3.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category acyl carrier protein
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes acp mutant has reduced ability to colonize and kill C. elegans
Reference 18771721

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 574 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000965 (679 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0995
Search term: acpP

Human Homologs

Ensembl 83, assembly GRCh38
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa [Source:HGNC Symbol;Acc:HGNC:7694]
E-value: 1.0e-10
Percent Identity: 41.7

References

Burkholderia cenocepacia J2315 acyl carrier protein: a potential target for antimicrobials' development?
Sousa SA(1), Ramos CG, Almeida F, Meirinhos-Soares L, Wopperer J, Schwager S, Eberl L, Leitão JH.
Microb Pathog. 2008 Nov-Dec;45(5-6):331-6.
PubMed ID: 18771721