Burkholderia cenocepacia J2315, BCAL0788 (pagL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0788
NCBI Locus TagQU43_RS40495
Name
pagL
Replicon chromosome 1
Genomic location 861084 - 861653 (+ strand)

Cross-References

RefSeq WP_006483740.1
GI 206559185
Entrez 6934096
GI 206559185
INSDC CAR51096.1
NCBI Locus Tag QU43_RS40495
NCBI Old Locus Tag BCAL0788
RefSeq WP_006483740.1,GeneID
UniParc UPI00017B90DA
UniProtKB Acc B4EAQ1
UniProtKB ID B4EAQ1_BURCJ
UniRef100 UniRef100_B4EAQ1
UniRef50 UniRef50_A0A063BAU7
UniRef90 UniRef90_B4EAQ1

Product

Feature Type CDS
Coding Frame 1
Product Name
Lipid A deacylase PagL
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 6.15
Kyte-Doolittle Hydrophobicity Value -0.273
Molecular Weight (kDa) 20869.4
Isoelectric Point (pI) 10.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 33 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002665 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0788
Search term: pagL

Human Homologs

References

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia.
Fathy Mohamed Y, Hamad M, Ortega XP, Valvano MA
Mol Microbiol 2017 Apr;104(1):144-162
PubMed ID: 28085228