Burkholderia cenocepacia J2315, BCAL0409 (paaF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL0409
NCBI Locus TagQU43_RS38580
Name
paaF
Replicon chromosome 1
Genomic location 443179 - 443955 (+ strand)

Cross-References

RefSeq WP_006491102.1
GI 206558815
Entrez 6933925
GI 206558815
INSDC CAR50720.1
NCBI Locus Tag QU43_RS38580
NCBI Old Locus Tag BCAL0409
RefSeq WP_006491102.1,GeneID
UniParc UPI00017B8ED7
UniProtKB Acc B4E7C0
UniProtKB ID B4E7C0_BURCJ
UniRef100 UniRef100_A0A095DTU6
UniRef50 UniRef50_A0R2Y5
UniRef90 UniRef90_A0A0B6RS26

Product

Feature Type CDS
Coding Frame 1
Product Name
enoyl-CoA hydratase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -3.37
Kyte-Doolittle Hydrophobicity Value 0.074
Molecular Weight (kDa) 27995.1
Isoelectric Point (pI) 5.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 508 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000434 (681 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0409
Search term: paaF

Human Homologs

Ensembl 83, assembly GRCh38
enoyl CoA hydratase, short chain, 1, mitochondrial [Source:HGNC Symbol;Acc:HGNC:3151]
E-value: 1.3e-75
Percent Identity: 56.4

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ(1), Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST.
J Bacteriol. 2008 Nov;190(21):7209-18.
PubMed ID: 18776009