Burkholderia cenocepacia J2315, BCAL0216 (paaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL0216
NCBI Locus TagQU43_RS37570
Name
paaA
Replicon chromosome 1
Genomic location 243264 - 244262 (- strand)

Cross-References

RefSeq WP_006482888.1
GI 206558623
Entrez 6933917
GI 206558623
INSDC CAR50527.1
NCBI Locus Tag QU43_RS37570
NCBI Old Locus Tag BCAL0216
RefSeq WP_006482888.1,GeneID
UniParc UPI00017B8FCF
UniProtKB Acc B4E5A2
UniProtKB ID B4E5A2_BURCJ
UniRef100 UniRef100_B4E5A2
UniRef50 UniRef50_Q4KBZ4
UniRef90 UniRef90_A1UZG5

Product

Feature Type CDS
Coding Frame 1
Product Name
phenylacetate-CoA oxygenase subunit PaaA
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -0.71
Kyte-Doolittle Hydrophobicity Value -0.425
Molecular Weight (kDa) 37042.6
Isoelectric Point (pI) 6.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Phenylacetic acid catabolism
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes paaA mutation diminishes virulence of B. cenocepacia K56-2 in the C. elegans model of infection
Reference 18776009

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 144 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000240 (677 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0216
Search term: paaA

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ(1), Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST.
J Bacteriol. 2008 Nov;190(21):7209-18.
PubMed ID: 18776009