Burkholderia cenocepacia J2315, BCAL0207 (hppD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL0207
NCBI Locus TagQU43_RS37525
Name
hppD
Replicon chromosome 1
Genomic location 236106 - 237203 (- strand)

Cross-References

RefSeq WP_006482885.1
GI 206558614
Entrez 6930832
GI 206558614
INSDC CAR50518.1
NCBI Locus Tag QU43_RS37525
NCBI Old Locus Tag BCAL0207
RefSeq WP_006482885.1,GeneID
UniParc UPI00017B8FC7
UniProtKB Acc B4E593
UniProtKB ID B4E593_BURCJ
UniRef100 UniRef100_B4E593
UniRef50 UniRef50_Q5ZT84
UniRef90 UniRef90_Q2STZ8

Product

Feature Type CDS
Coding Frame 1
Product Name
4-hydroxyphenylpyruvic acid dioxygenase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -7.40
Kyte-Doolittle Hydrophobicity Value -0.390
Molecular Weight (kDa) 41127.1
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category Response to superoxide
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Mus musculus
Notes hppD mutation has bacterial intracellular survival in RAW 264.7 macrophages
Reference 17933889

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 221 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000231 (679 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0207
Search term: hppD

Human Homologs

Ensembl 83, assembly GRCh38
4-hydroxyphenylpyruvate dioxygenase-like [Source:HGNC Symbol;Acc:HGNC:28242]
E-value: 5.9e-13
Percent Identity: 32.0

References

Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate.
Keith KE, Killip L, He P, Moran GR, Valvano MA.
J Bacteriol. 2007 Dec;189(24):9057-65.
PubMed ID: 17933889