Burkholderia pseudomallei 668, BURPS668_A2180 (bsaL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2180
NCBI Locus TagBURPS668_RS25980
Name
bsaL
Synonym: yscF
Replicon chromosome II
Genomic location 2116698 - 2116967 (+ strand)

Cross-References

RefSeq WP_004187639.1
GI 126443759
Entrez 4887959
GI 126443759
INSDC ABN86755.1
NCBI Locus Tag BURPS668_RS25980
NCBI Old Locus Tag BURPS668_A2180
RefSeq WP_004187639.1
UniParc UPI0000441485
UniProtKB Acc A3NLF3
UniProtKB ID A3NLF3_BURP6
UniRef100 UniRef100_A0A095M298
UniRef50 UniRef50_Q2T727
UniRef90 UniRef90_Q2T727

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system needle protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -2.02
Kyte-Doolittle Hydrophobicity Value -0.620
Molecular Weight (kDa) 9923.9
Isoelectric Point (pI) 4.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2G0U UNKNOWN FUNCTION 02/13/06 Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 98.8

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 12 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019858 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2180
Search term: bsaL

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592