Burkholderia pseudomallei 668, BURPS668_A2162 (bipB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2162
NCBI Locus TagBURPS668_RS25900
Name
bipB
Synonym: ipaB
Replicon chromosome II
Genomic location 2099241 - 2101103 (- strand)

Cross-References

RefSeq WP_011853456.1
GI 126443663
Entrez 4888375
GI 126443663
INSDC ABN86659.1
NCBI Locus Tag BURPS668_RS25900
NCBI Old Locus Tag BURPS668_A2162
RefSeq WP_011853456.1
UniParc UPI0000F28B34
UniProtKB Acc A3NLD5
UniProtKB ID BIPB_BURP6
UniRef100 UniRef100_A3NLD5
UniRef50 UniRef50_Q2T711
UniRef90 UniRef90_Q2T711

Product

Feature Type CDS
Coding Frame 1
Product Name
BipB protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -2.89
Kyte-Doolittle Hydrophobicity Value -0.085
Molecular Weight (kDa) 64674.1
Isoelectric Point (pI) 6.13

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Host Associated
Note: This is based on PSORTb V3.0 secondary localization prediction
 Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019834 (323 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2162
Search term: bipB
Search term: BipB protein

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.
Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ
Mol Microbiol 2007 Mar;63(6):1719-30
PubMed ID: 17367391