Burkholderia pseudomallei 668, BURPS668_A2155 (bopE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 668
GCF_000015905.1|latest
Locus Tag
BURPS668_A2155
NCBI Locus TagBURPS668_RS25865
Name
bopE
Replicon chromosome II
Genomic location 2091663 - 2092448 (+ strand)

Cross-References

RefSeq WP_004528812.1
GI 126442508
Entrez 4887362
GI 126442508
INSDC ABN85504.1
NCBI Locus Tag BURPS668_RS25865
NCBI Old Locus Tag BURPS668_A2155
RefSeq WP_004528812.1
UniParc UPI000043BD17
UniProtKB Acc A3NLC8
UniProtKB ID BOPE_BURP6
UniRef100 UniRef100_Q3JL30
UniRef50 UniRef50_Q2T704
UniRef90 UniRef90_Q2T704

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion target BopE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 8.14
Kyte-Doolittle Hydrophobicity Value -0.544
Molecular Weight (kDa) 28705.0
Isoelectric Point (pI) 9.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2JOL CELL INVASION, SIGNALING PROTEIN 03/14/07 Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 100.0
2JOK CELL INVASION, SIGNALING PROTEIN 03/14/07 NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 100.0

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019825 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS668_A2155
Search term: bopE

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592