Burkholderia multivorans ATCC 17616, Bmul_3336 (hmuT)

Gene Feature Overview

Strain	Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1 GCF_000018505.1|latest
Locus Tag	Bmul_3336
NCBI Locus Tag	BMUL_RS16890
Name	hmuT
Replicon	chromosome 2
Genomic location	220885 - 221799 (- strand)
Comment	Member of the hemin uptake (hmu) operon

Cross-References

RefSeq	WP_012216314.1
GI	161519885
Entrez	5768422
GI	161519885
NCBI Locus Tag	BMUL_RS16890
NCBI Old Locus Tag	Bmul_3336
RefSeq	WP_012216314.1
UniProtKB Acc	A9ALR3
UniProtKB ID	A9ALR3_BURM1

Product

Feature Type	CDS
Coding Frame	1
Product Name	periplasmic heme-binding protein HmuT
Synonyms	periplasmic binding protein
Evidence for Translation
Charge (pH 7)	9.65
Kyte-Doolittle Hydrophobicity Value	0.185
Molecular Weight (kDa)	31227.4
Isoelectric Point (pI)	10.53

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 291 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004244 (594 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: Bmul_3336 Search term: hmuT Search term: periplasmic heme-binding protein HmuT

Human Homologs

References

The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616. Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M Appl Environ Microbiol 2017 Aug 15;83(16) PubMed ID: 28625994

Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis. Kvitko BH, Goodyear A, Propst KL, Dow SW, Schweizer HP PLoS Negl Trop Dis 2012;6(6):e1715 PubMed ID: 22745846