Burkholderia multivorans ATCC 17616, Bmul_3334 (hmuV)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_3334
NCBI Locus TagBMUL_RS16880
Name
hmuV
Replicon chromosome 2
Genomic location 218920 - 219762 (- strand)
CommentMember of the hemin uptake (hmu) operon

Cross-References

RefSeq WP_012216312.1
GI 161519883
Entrez 5768663
GI 161519883
NCBI Locus Tag BMUL_RS16880
NCBI Old Locus Tag Bmul_3334
RefSeq WP_012216312.1
UniProtKB Acc A9ALR1
UniProtKB ID A9ALR1_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-binding cassette subunit of inner membrane heme transporter HmuV
Synonyms hemin importer ATP-binding subunit
Evidence for Translation
Charge (pH 7) 8.85
Kyte-Doolittle Hydrophobicity Value -0.050
Molecular Weight (kDa) 30169.3
Isoelectric Point (pI) 10.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 668 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004246 (596 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_3334
Search term: hmuV

Human Homologs

Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 8 [Source:HGNC Symbol;Acc:HGNC:49]
E-value: 1.5e-09
Percent Identity: 27.1
Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 8 [Source:HGNC Symbol;Acc:HGNC:49]
E-value: 1.5e-09
Percent Identity: 27.1
Ensembl 97, assembly GRCh38.p12
ATP binding cassette subfamily B member 8 [Source:HGNC Symbol;Acc:HGNC:49]
E-value: 1.5e-09
Percent Identity: 27.1

References

The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616.
Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M
Appl Environ Microbiol 2017 Aug 15;83(16)
PubMed ID: 28625994
Burkholderia pseudomallei known siderophores and hemin uptake are dispensable for lethal murine melioidosis.
Kvitko BH, Goodyear A, Propst KL, Dow SW, Schweizer HP
PLoS Negl Trop Dis 2012;6(6):e1715
PubMed ID: 22745846