Burkholderia dolosa AU0158, AK34_RS08380 (rpfR)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia dolosa AU0158 (complete genome)
GCF_000959505.1|latest |
| Locus Tag |
AK34_RS08380
|
| NCBI Old Locus Tag | AK34_4835 |
| Name |
rpfR
Synonym: BDAG_04275 |
| Replicon | chromosome 2 |
| Genomic location | 1923734 - 1925737 (- strand) |
Cross-References
| RefSeq | WP_035974932.1 |
| GI | 738013551 |
| NCBI Locus Tag | AK34_RS08380 |
| NCBI Old Locus Tag | AK34_4835 |
| RefSeq | WP_035974932.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
cis-2-dodecenoic acid receptor RpfR
|
| Synonyms |
RNase II stability modulator |
| Evidence for Translation | |
| Charge (pH 7) | -11.54 |
| Kyte-Doolittle Hydrophobicity Value | -0.059 |
| Molecular Weight (kDa) | 73405.5 |
| Isoelectric Point (pI) | 5.93 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG004646 (511 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: AK34_RS08380
Search term: rpfR
Search term: cis-2-dodecenoic acid receptor RpfR
|
Human Homologs
References
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Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15479-84
PubMed ID: 22949660
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Mutation of the cyclic di-GMP phosphodiesterase gene in Burkholderia lata SK875 attenuates virulence and enhances biofilm formation.
Jung HI, Kim YJ, Lee YJ, Lee HS, Lee JK, Kim SK
J Microbiol 2017 Oct;55(10):800-808
PubMed ID: 28956352
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High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111.
Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L
Microbiology 2017 May;163(5):754-764
PubMed ID: 28463102
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Cis-2-dodecenoic acid quorum sensing system modulates N-acyl homoserine lactone production through RpfR and cyclic di-GMP turnover in Burkholderia cenocepacia.
Deng Y, Lim A, Wang J, Zhou T, Chen S, Lee J, Dong YH, Zhang LH
BMC Microbiol 2013 Jul 1;13:148
PubMed ID: 23815566
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