Burkholderia mallei NCTC 10229, BMA10229_2080 (bopE)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia mallei NCTC 10229
GCF_000015605.1|latest |
| Locus Tag |
BMA10229_2080
|
| NCBI Locus Tag | BMA10229_RS09020 |
| Name |
bopE
|
| Replicon | chromosome II |
| Genomic location | 2132817 - 2133602 (- strand) |
Cross-References
| RefSeq | WP_004188462.1 |
| GI | 124381526 |
| Entrez | 4789210 |
| GI | 124381526 |
| INSDC | ABN00329.2 |
| NCBI Locus Tag | BMA10229_RS09020 |
| NCBI Old Locus Tag | BMA10229_2080 |
| RefSeq | WP_004188462.1 |
| UniParc | UPI0000441477 |
| UniProtKB Acc | A2S1Q7 |
| UniProtKB Acc | A2S1Q7 |
| UniProtKB ID | A2S1Q5_BURM9 |
| UniProtKB ID | BOPE_BURM9 |
| UniRef100 | UniRef100_A3MCH6 |
| UniRef50 | UniRef50_Q2T704 |
| UniRef90 | UniRef90_Q2T704 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
type III secretion target BopE
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 8.14 |
| Kyte-Doolittle Hydrophobicity Value | -0.553 |
| Molecular Weight (kDa) | 28735.0 |
| Isoelectric Point (pI) | 9.89 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
| Look for predicted 3D structure in AlphaFold DB: Search |
| Look for predicted 3D structure in AlphaFold DB: Search |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2JOK | CELL INVASION, SIGNALING PROTEIN | 03/14/07 | NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | NOT | SOLUTION NMR | 99.5 |
| 2JOL | CELL INVASION, SIGNALING PROTEIN | 03/14/07 | Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | NOT | SOLUTION NMR | 99.5 |
Virulence Evidence
| Source 1 | |
| Database | VFDB : VF0428 |
| Category | T3SS-3 |
| Evidence |
ECO:0000250
sequence similarity evidence used in manual assertion
|
| Host Organism | |
| Notes | |
| Annotation transferred from | Burkholderia pseudomallei K96243 |
| Reference | 17984080 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera
|
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG019825 (316 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BMA10229_2080
Search term: bopE
Search term: type III secretion target BopE
|
Human Homologs
References
|
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
|