Burkholderia ambifaria MC40-6, BamMC406_0785 (kdoO)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia ambifaria MC40-6
GCF_000019925.1|latest
Locus Tag
BamMC406_0785
NCBI Locus TagBAMMC406_RS04005
Name
kdoO
Replicon chromosome 1
Genomic location 879052 - 879936 (+ strand)
CommentResponsible for Ko formation with Kdo2-lipid A as a substrate

Cross-References

RefSeq WP_011656152.1
GI 172059845
Entrez 6178954
GI 172059845
NCBI Locus Tag BAMMC406_RS04005
NCBI Old Locus Tag BamMC406_0785
RefSeq WP_011656152.1
UniProtKB Acc B1YUF4
UniProtKB ID B1YUF4_BURA4

Product

Feature Type CDS
Coding Frame 1
Product Name
Kdo 3-hydroxylase KdoO
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 3.59
Kyte-Doolittle Hydrophobicity Value -0.237
Molecular Weight (kDa) 32807.4
Isoelectric Point (pI) 8.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 28 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000751 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BamMC406_0785
Search term: kdoO

Human Homologs

References

Dioxygenases in Burkholderia ambifaria and Yersinia pestis that hydroxylate the outer Kdo unit of lipopolysaccharide.
Chung HS, Raetz CR
Proc Natl Acad Sci U S A 2011 Jan 11;108(2):510-5
PubMed ID: 21178073
Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis.
Chung HS, Yang EG, Hwang D, Lee JE, Guan Z, Raetz CR
Biochem Biophys Res Commun 2014 Sep 26;452(3):789-94
PubMed ID: 25204504