Burkholderia vietnamiensis G4, Bcep1808_2731 (htrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia vietnamiensis G4
GCF_000016205.1|latest
Locus Tag
Bcep1808_2731
NCBI Locus TagBCEP1808_RS13675
Name
htrA
Replicon chromosome 1
Genomic location 3022079 - 3023563 (- strand)

Cross-References

RefSeq WP_011885898.1
GI 134296822
Entrez 4954475
GI 134296822
INSDC ABO55722.1
NCBI Locus Tag BCEP1808_RS13675
NCBI Old Locus Tag Bcep1808_2731
RefSeq WP_011885898.1
UniParc UPI00003A6158
UniProtKB Acc A4JHG9
UniProtKB ID A4JHG9_BURVG
UniRef100 UniRef100_A4JHG9
UniRef50 UniRef50_Q1LH84
UniRef90 UniRef90_B1YVV2

Product

Feature Type CDS
Coding Frame 1
Product Name
protease Do
Product Name Confidence: Class 2
Synonyms HtrA protease
Evidence for Translation
Charge (pH 7) 2.44
Kyte-Doolittle Hydrophobicity Value -0.031
Molecular Weight (kDa) 50977.5
Isoelectric Point (pI) 8.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 615 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002475 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bcep1808_2731
Search term: htrA
Search term: protease Do

Human Homologs

Ensembl 97, assembly GRCh38.p12
HtrA serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:14348]
E-value: 3.3e-36
Percent Identity: 37.1

References

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.
Flannagan RS, Aubert D, Kooi C, Sokol PA, Valvano MA
Infect Immun 2007 Apr;75(4):1679-89
PubMed ID: 17220310