Burkholderia vietnamiensis G4, Bcep1808_0749 (caiA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia vietnamiensis G4
GCF_000016205.1|latest
Locus Tag
Bcep1808_0749
NCBI Locus TagBCEP1808_RS03760
Name
caiA
Replicon chromosome 1
Genomic location 822622 - 823809 (- strand)

Cross-References

RefSeq WP_011883419.1
GI 134294861
Entrez 4952445
GI 134294861
INSDC ABO53761.1
NCBI Locus Tag BCEP1808_RS03760
NCBI Old Locus Tag Bcep1808_0749
RefSeq WP_011883419.1
UniParc UPI000053273A
UniProtKB Acc A4JBV8
UniProtKB ID A4JBV8_BURVG
UniRef100 UniRef100_A4JBV8
UniRef50 UniRef50_Q92947
UniRef90 UniRef90_Q0K7X5

Product

Feature Type CDS
Coding Frame 1
Product Name
acyl-CoA dehydrogenase domain-containing protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -3.19
Kyte-Doolittle Hydrophobicity Value -0.136
Molecular Weight (kDa) 43217.1
Isoelectric Point (pI) 6.32

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3II9 OXIDOREDUCTASE 07/31/09 Crystal structure of glutaryl-coa dehydrogenase from Burkholderia pseudomallei at 1.73 Angstrom BURKHOLDERIA PSEUDOMALLEI 1710B 1.74 X-RAY DIFFRACTION 93.4
3GQT OXIDOREDUCTASE 03/24/09 Crystal structure of glutaryl-CoA dehydrogenase from Burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methylamine BURKHOLDERIA PSEUDOMALLEI 1.99 X-RAY DIFFRACTION 93.4
3GNC OXIDOREDUCTASE 03/16/09 Crystal structure of Glutaryl-COA dehydrogenase from Burkholderia Pseudomallei with fragment 6421 BURKHOLDERIA PSEUDOMALLEI 2.15 X-RAY DIFFRACTION 93.4
3D6B OXIDOREDUCTASE 05/19/08 2.2 A crystal structure of glutaryl-CoA dehydrogenase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.21 X-RAY DIFFRACTION 93.4
3EON OXIDOREDUCTASE 09/28/08 2.55A crystal structure of native glutaryl-coa dehydrogenase from Burkholderia pseudomallei in complex with a small molecule BURKHOLDERIA PSEUDOMALLEI 2.55 X-RAY DIFFRACTION 93.4
3EOM OXIDOREDUCTASE 09/28/08 2.4 A crystal structure of native glutaryl-coa dehydrogenase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.398 X-RAY DIFFRACTION 93.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 470 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000676 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bcep1808_0749
Search term: caiA

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutaryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4189]
E-value: 6.9e-146
Percent Identity: 66.5
Ensembl 97, assembly GRCh38.p12
glutaryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4189]
E-value: 6.9e-146
Percent Identity: 66.5

References

Identification of potential CepR regulated genes using a cep box motif-based search of the Burkholderia cenocepacia genome.
Chambers CE, Lutter EI, Visser MB, Law PP, Sokol PA
BMC Microbiol 2006 Dec 22;6:104
PubMed ID: 17187664