Burkholderia thailandensis E264 ATCC 700388, BTH_I2392 (mftP )

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_I2392
NCBI Locus TagBTH_RS24405
Name
mftP
Replicon chromosome I
Genomic location 2719609 - 2720781 (+ strand)
Transposon Mutants 1 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_442913.1
GI 83718476
Entrez 3847011
GI 83718476
NCBI Locus Tag BTH_RS24405
NCBI Old Locus Tag BTH_I2392
RefSeq WP_011402355.1
UniProtKB Acc Q2SVY6
UniProtKB ID Q2SVY6_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
major facilitator transport protein MftP
Product Name Confidence: Class 1
Synonyms major facilitator family transporter
Evidence for Translation
Charge (pH 7) 13.61
Kyte-Doolittle Hydrophobicity Value 1.021
Molecular Weight (kDa) 39003.8
Isoelectric Point (pI) 11.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 174 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001498 (611 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_I2392
Search term: mftP

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Ligand-binding pocket bridges DNA-binding and dimerization domains of the urate-responsive MarR homologue MftR from Burkholderia thailandensis.
Gupta A, Grove A
Biochemistry 2014 Jul 15;53(27):4368-80
PubMed ID: 24955985
Urate-responsive MarR homologs from Burkholderia.
Grove A
Mol Biosyst 2010 Nov;6(11):2133-42
PubMed ID: 20730247