Burkholderia thailandensis E264 ATCC 700388, BTH_I1471 (rmlC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_I1471
NCBI Locus TagBTH_RS19705
Name
rmlC
Replicon chromosome I
Genomic location 1666654 - 1667205 (+ strand)
Transposon Mutants 3 transposon mutants in E264 ATCC 700388
CommentBelongs to the Type II O-antigenic polysaccharide biosynthesis gene cluster

Cross-References

RefSeq YP_442017.1
GI 83720588
Entrez 3849950
GI 83720588
NCBI Locus Tag BTH_RS19705
NCBI Old Locus Tag BTH_I1471
RefSeq WP_009889585.1
UniProtKB Acc Q2SYI2
UniProtKB ID Q2SYI2_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
dTDP-6-deoxy-d-xylo-4-hexulose 3,5-epimerase RmlC
Product Name Confidence: Class 1
Synonyms dTDP-4-dehydrorhamnose 3,5-epimerase
Evidence for Translation
Charge (pH 7) -6.04
Kyte-Doolittle Hydrophobicity Value -0.178
Molecular Weight (kDa) 20650.2
Isoelectric Point (pI) 4.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 471 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000732 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_I1471
Search term: rmlC

Human Homologs

References

A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis.
Yoo HG, Kwon SY, Karki S, Kwon HJ
Bioorg Med Chem Lett 2011 Jul 1;21(13):3914-7
PubMed ID: 21640586