Burkholderia thailandensis E264 ATCC 700388, BTH_I1469 (rmlB)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_I1469
NCBI Locus Tag	BTH_RS19695
Name	rmlB Synonym: rfbB
Replicon	chromosome I
Genomic location	1664571 - 1665764 (+ strand)
Transposon Mutants	1 transposon mutants in E264 ATCC 700388
Comment	Belongs to the Type II O-antigenic polysaccharide biosynthesis gene cluster

Cross-References

RefSeq	YP_442015.1
GI	83719152
Entrez	3846928
GI	83719152
INSDC	ABC37040.1
NCBI Locus Tag	BTH_RS19695
NCBI Old Locus Tag	BTH_I1469
RefSeq	YP_442015.1
UniParc	UPI0000667E25
UniProtKB Acc	Q2SYI4
UniProtKB ID	Q2SYI4_BURTA
UniRef100	UniRef100_G3LYM6
UniRef50	UniRef50_P55294
UniRef90	UniRef90_E5GAJ4

Product

Feature Type	CDS
Coding Frame	1
Product Name	dTDP-d-glucose 4,6-dehydratase RmlB Product Name Confidence: Class 1
Synonyms	dTDP-glucose 4,6-dehydratase
Evidence for Translation
Charge (pH 7)	-3.79
Kyte-Doolittle Hydrophobicity Value	-0.348
Molecular Weight (kDa)	43758.7
Isoelectric Point (pI)	6.51

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 643 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000730 (655 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_I1469 Search term: rmlB Search term: dTDP-d-glucose 4,6-dehydratase RmlB

Human Homologs

References

A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis. Yoo HG, Kwon SY, Karki S, Kwon HJ Bioorg Med Chem Lett 2011 Jul 1;21(13):3914-7 PubMed ID: 21640586