Burkholderia thailandensis E264 ATCC 700388, BTH_II2098 (malL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2098
NCBI Locus TagBTH_RS10735
Name
malL
Synonym: fabD-2
Replicon chromosome II
Genomic location 2576869 - 2577768 (+ strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388
CommentBelongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq YP_440286.1
GI 83717685
Entrez 3844925
GI 83717685
NCBI Locus Tag BTH_RS10735
NCBI Old Locus Tag BTH_II2098
RefSeq WP_009894058.1
UniProtKB Acc Q2T3G3
UniProtKB ID Q2T3G3_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
MalL
Synonyms malonyl CoA-acyl carrier protein transacylase
Evidence for Translation
Charge (pH 7) -6.40
Kyte-Doolittle Hydrophobicity Value 0.026
Molecular Weight (kDa) 31993.0
Isoelectric Point (pI) 5.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 571 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019791 (369 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2098
Search term: malL
Search term: MalL

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Biggins JB, Ternei MA, Brady SF
J Am Chem Soc 2012 Aug 15;134(32):13192-5
PubMed ID: 22765305