Burkholderia thailandensis E264 ATCC 700388, BTH_II1935 (hmqA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1935
NCBI Locus TagBTH_RS09900
Name
hmqA
Replicon chromosome II
Genomic location 2354118 - 2355743 (- strand)
Transposon Mutants 5 transposon mutants in E264 ATCC 700388
CommentBelongs to the HMAQ biosynthesis operon hmqABCDEFG

Cross-References

RefSeq YP_440129.1
GI 83716442
Entrez 3845045
GI 83716442
INSDC AIP29043.1
NCBI Locus Tag BTH_RS09900
NCBI Old Locus Tag BTH_II1935
RefSeq WP_009893833.1
UniParc UPI00006673EA
UniProtKB Acc Q2T3X0
UniProtKB ID Q2T3X0_BURTA
UniRef100 UniRef100_Q2T3X0
UniRef50 UniRef50_A4YQI1
UniRef90 UniRef90_A3NHC2

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-CoA synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -1.32
Kyte-Doolittle Hydrophobicity Value 0.009
Molecular Weight (kDa) 58518.3
Isoelectric Point (pI) 6.85

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 602 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017403 (474 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1935
Search term: hmqA

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase medium chain family member 3 [Source:HGNC Symbol;Acc:HGNC:10522]
E-value: 3.6e-52
Percent Identity: 28.8

References

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation.
Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E
J Bacteriol 2008 Aug;190(15):5339-52
PubMed ID: 18539738
Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain.
Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E
Front Microbiol 2017;8:1021
PubMed ID: 28676791