Burkholderia thailandensis E264 ATCC 700388, BTH_II1681 (thaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1681
NCBI Locus TagBTH_RS08595
Name
thaA
Replicon chromosome II
Genomic location 2036259 - 2036975 (- strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_439875.1
GI 83716249
Entrez 3845972
GI 83716249
NCBI Locus Tag BTH_RS08595
NCBI Old Locus Tag BTH_II1681
RefSeq YP_439875.1
UniProtKB Acc Q2T4M4
UniProtKB ID Q2T4M4_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
ThaA
Synonyms ATP-dependent transcription regulator LuxR
Evidence for Translation
Charge (pH 7) -1.13
Kyte-Doolittle Hydrophobicity Value -0.108
Molecular Weight (kDa) 26135.4
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 112 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG021637 (14 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1681
Search term: thaA
Search term: ThaA

Human Homologs

References

Correction to Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2018 Jan 19;13(1):282
PubMed ID: 29283242
Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant.
Ishida K, Lincke T, Behnken S, Hertweck C
J Am Chem Soc 2010 Oct 13;132(40):13966-8
PubMed ID: 20853892