Burkholderia thailandensis E264 ATCC 700388, BTH_II1278

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1278
NCBI Locus TagBTH_RS06540
Name
Replicon chromosome II
Genomic location 1521863 - 1523266 (- strand)
Transposon Mutants 2 transposon mutants in E264 ATCC 700388
CommentMember of the toxoflavin-like gene cluster

Cross-References

RefSeq YP_439474.1
GI 83716065
Entrez 3845098
GI 83716065
INSDC AIP29311.1
NCBI Locus Tag BTH_RS06540
NCBI Old Locus Tag BTH_II1278
RefSeq WP_011401219.1
UniParc UPI000066727B
UniProtKB Acc Q2T5S5
UniProtKB ID Q2T5S5_BURTA
UniRef100 UniRef100_Q2T5S5
UniRef50 UniRef50_F2LP90
UniRef90 UniRef90_Q63L80

Product

Feature Type CDS
Coding Frame 1
Product Name
major facilitator superfamily protein
Synonyms
Evidence for Translation
Charge (pH 7) 16.03
Kyte-Doolittle Hydrophobicity Value 0.999
Molecular Weight (kDa) 47467.7
Isoelectric Point (pI) 10.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 420 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG018048 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1278

Human Homologs

References

Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B
Biochemistry 2017 Aug 1;56(30):3934-3944
PubMed ID: 28665591