Burkholderia thailandensis E264 ATCC 700388, BTH_II0132

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II0132
NCBI Locus TagBTH_RS00675
Name
Replicon chromosome II
Genomic location 157593 - 158975 (- strand)
Transposon Mutants 3 transposon mutants in E264 ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-2 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_438334.1
GI 83716926
Entrez 3846142
GI 83716926
INSDC ABC34815.1
NCBI Locus Tag BTH_RS00675
NCBI Old Locus Tag BTH_II0132
RefSeq YP_438334.1
UniParc UPI00006675C1
UniProtKB Acc Q2T915
UniProtKB ID Q2T915_BURTA
UniRef100 UniRef100_Q2T915
UniRef50 UniRef50_A0A095RN58
UniRef90 UniRef90_A0A095SMW1

Product

Feature Type CDS
Coding Frame 1
Product Name
hypothetical protein
Synonyms
Evidence for Translation
Charge (pH 7) -2.94
Kyte-Doolittle Hydrophobicity Value -0.422
Molecular Weight (kDa) 52838.8
Isoelectric Point (pI) 6.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020421 (331 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0132

Human Homologs

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170