Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSS1533
|
Name |
bicA
|
Replicon | chromosome 2 |
Genomic location | 2087441 - 2087956 (- strand) |
Comment | This gene is part of the type III secretion system T3SS-3 (bsa) gene locus. The B. pseudomallei bicA gene is able to partially complement a Salmonella sicA mutant, supporting a homologous function as chaperone (PMID:27997726). |
RefSeq | YP_111539.1 |
GI | 53722554 |
Entrez | 3096042 |
GI | 53722554 |
INSDC | CAH39006.1 |
NCBI Locus Tag | BPSS1533 |
RefSeq | YP_111539.1,GeneID |
UniParc | UPI000043BD1F |
UniProtKB Acc | Q63K33 |
UniProtKB ID | Q63K33_BURPS |
UniRef100 | UniRef100_A0A069B9Y9 |
UniRef50 | UniRef50_Q7NUS7 |
UniRef90 | UniRef90_I1WUC1 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
type III secretion chaperone protein BicA (T3SS-3)
|
Synonyms |
surface presentation of antigens protein |
Evidence for Translation |
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (16.0 kDa, pI 6.00, PMID:21960737)
|
Charge (pH 7) | -7.93 |
Kyte-Doolittle Hydrophobicity Value | -0.227 |
Molecular Weight (kDa) | 19198.5 |
Isoelectric Point (pI) | 4.71 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | VFDB : VF0428 |
Category | T3SS-3 |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | |
Notes | |
Reference | 17984080 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 28 genera
|
Burkholderia Ortholog Group |
BG019836 (323 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSS1533
Search term: bicA
Search term: type III secretion chaperone protein BicA (T3SS-3)
|
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
|
Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium.
Darwin KH, Miller VL
EMBO J 2001 Apr 17;20(8):1850-62
PubMed ID: 11296219
|
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
|
Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei.
Sun GW, Chen Y, Liu Y, Tan GY, Ong C, Tan P, Gan YH
Mol Microbiol 2010 May;76(3):677-89
PubMed ID: 20345664
|
Characterization and analysis of the Burkholderia pseudomallei BsaN virulence regulon.
Chen Y, Schröder I, French CT, Jaroszewicz A, Yee XJ, Teh BE, Toesca IJ, Miller JF, Gan YH
BMC Microbiol 2014 Aug 1;14:206
PubMed ID: 25085508
|
Functional relatedness in the Inv/Mxi-Spa type III secretion system family.
Klein JA, Dave BM, Raphenya AR, McArthur AG, Knodler LA
Mol Microbiol 2017 Mar;103(6):973-991
PubMed ID: 27997726
|