Burkholderia pseudomallei K96243, BPSS1531 (bipC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1531
Name
bipC
Synonym: sctB
Replicon chromosome 2
Genomic location 2084259 - 2085518 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111537.1
GI 53722552
Entrez 3096209
GI 53722552
INSDC CAH39004.1
NCBI Locus Tag BPSS1531
RefSeq YP_111537.1,GeneID
UniParc UPI000043BD1D
UniProtKB Acc Q63K35
UniProtKB ID BIPC_BURPS
UniRef100 UniRef100_A3MCG9
UniRef50 UniRef50_A3MCG9
UniRef90 UniRef90_A3MCG9

Product

Feature Type CDS
Coding Frame 1
Product Name
translocator protein BipC (T3SS-3)
Product Name Confidence: Class 2
Synonyms cell invasion protein
Evidence for Translation
Charge (pH 7) 4.63
Kyte-Doolittle Hydrophobicity Value -0.583
Molecular Weight (kDa) 44322.2
Isoelectric Point (pI) 8.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Host Associated
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in 2 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019833 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1531
Search term: bipC

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
BipC, a Predicted <i>Burkholderia pseudomallei</i> Type 3 Secretion System Translocator Protein with Actin Binding Activity.
Vander Broek CW, Zainal Abidin N, Stevens JM
Front Cell Infect Microbiol 2017;7:333
PubMed ID: 28770177
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Eukaryotic pathways targeted by the type III secretion system effector protein, BipC, involved in the intracellular lifecycle of Burkholderia pseudomallei.
Kang WT, Vellasamy KM, Vadivelu J
Sci Rep 2016 Sep 16;6:33528
PubMed ID: 27634329
<i>Burkholderia pseudomallei</i> type III secreted protein BipC: role in actin modulation and translocation activities required for the bacterial intracellular lifecycle.
Kang WT, Vellasamy KM, Rajamani L, Beuerman RW, Vadivelu J
PeerJ 2016;4:e2532
PubMed ID: 28028452