Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSS1529
|
Name |
bipD
Synonym: ipaD Synonym: sctA |
Replicon | chromosome 2 |
Genomic location | 2082841 - 2083773 (- strand) |
Comment | This gene is part of the type III secretion system T3SS-3 (bsa) gene locus. |
RefSeq | YP_111535.1 |
GI | 53722550 |
Entrez | 3096115 |
GI | 53722550 |
INSDC | CAH39002.1 |
NCBI Locus Tag | BPSS1529 |
RefSeq | YP_111535.1,GeneID |
UniParc | UPI000043BD1B |
UniProtKB Acc | Q63K37 |
UniProtKB ID | BIPD_BURPS |
UniRef100 | UniRef100_A3MCH1 |
UniRef50 | UniRef50_Q2T708 |
UniRef90 | UniRef90_A3MCH1 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
type III secretion system needle tip protein BipD (T3SS-3)
|
Synonyms |
membrane antigen |
Evidence for Translation |
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (30.0 kDa, pI 4.95, PMID:21960737)
|
Charge (pH 7) | -7.03 |
Kyte-Doolittle Hydrophobicity Value | -0.362 |
Molecular Weight (kDa) | 33975.1 |
Isoelectric Point (pI) | 4.96 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3NFT | TRANSPORT PROTEIN | 06/10/10 | Near-atomic resolution analysis of BipD- A component of the type-III secretion system of Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 1.51 | X-RAY DIFFRACTION | 99.7 |
2J9T | TOXIN | 11/16/06 | BipD of Burkholderia Pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.7 | X-RAY DIFFRACTION | 99.7 |
2IZP | TOXIN | 07/25/06 | BipD - an invasion protein associated with the type-III secretion system of Burkholderia pseudomallei. | BURKHOLDERIA PSEUDOMALLEI | 2.1 | X-RAY DIFFRACTION | 99.7 |
2IXR | TOXIN | 07/10/06 | BipD of Burkholderia Pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.6 | X-RAY DIFFRACTION | 99.7 |
Source 1 | |
Database | VFDB : VF0428 |
Category | T3SS-3 |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | |
Notes | |
Reference | 17984080 |
Source 2 | |
Database | Victors : 1984 |
Category | |
Evidence |
ECO:0000015
mutant phenotype evidence
|
Host Organism | Mus musculus |
Notes | bipD mutant was attenuated in mice |
Reference | 16987331 |
Source 3 | |
Database | BGD |
Category | T3SS-3 |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | bipD mutant has reduced intracellular replication in J774.2 murine macrophage-like cells |
Reference | 12410823 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera
|
Burkholderia Ortholog Group |
BG019830 (320 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSS1529
Search term: bipD
|
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
|
Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei.
Pal M, Erskine PT, Gill RS, Wood SP, Cooper JB
Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Sep 1;66(Pt 9):990-3
PubMed ID: 20823511
|
An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen.
Stevens MP, Wood MW, Taylor LA, Monaghan P, Hawes P, Jones PW, Wallis TS, Galyov EE
Mol Microbiol 2002 Nov;46(3):649-59
PubMed ID: 12410823
|
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
|
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
|