Burkholderia pseudomallei K96243, BPSS1522 (bprB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1522
Name
bprB
Replicon chromosome 2
Genomic location 2074346 - 2075017 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111528.1
GI 53722543
Entrez 3096722
GI 53722543
INSDC CAH38995.1
NCBI Locus Tag BPSS1522
RefSeq YP_111528.1,GeneID
UniParc UPI000043BD14
UniProtKB Acc Q63K44
UniProtKB ID Q63K44_BURPS
UniRef100 UniRef100_Q62B18
UniRef50 UniRef50_Q2T701
UniRef90 UniRef90_Q2T701

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.05
Kyte-Doolittle Hydrophobicity Value -0.005
Molecular Weight (kDa) 24252.8
Isoelectric Point (pI) 8.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 576 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019820 (326 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1522
Search term: bprB

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Transcriptome analysis of Burkholderia pseudomallei T6SS identifies Hcp1 as a potential serodiagnostic marker.
Chieng S, Mohamed R, Nathan S
Microb Pathog 2015 Feb;79:47-56
PubMed ID: 25616255
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152