Burkholderia pseudomallei K96243, BPSS1504 (tagAB-5)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
BPSS1504
Name
tagAB-5
Replicon chromosome 2
Genomic location 2052905 - 2055547 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-5 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:21670170, PMID:22007185) and by the B. mallei literature (PMID:22892068, PMID:17555434).

Cross-References

RefSeq YP_111511.1
GI 53722526
Entrez 3095587
GI 53722526
INSDC CAH38977.1
NCBI Locus Tag BPSS1504
RefSeq YP_111511.1,GeneID
UniParc UPI000043BD03
UniProtKB Acc Q63K61
UniProtKB ID Q63K61_BURPS
UniRef100 UniRef100_Q63K61
UniRef50 UniRef50_I1WU91
UniRef90 UniRef90_I1WU91

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagAB-5
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -27.10
Kyte-Doolittle Hydrophobicity Value -0.170
Molecular Weight (kDa) 91342.3
Isoelectric Point (pI) 5.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database BGD
Category T6SS-1
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes BPSS1504 is attenuated for virulence in BALB/c mice
Reference 24595140
Source 2
Database VFDB : VF0429
Category T6SS-1
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 242 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001150 (550 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1504
Search term: tagAB-5

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 24595140
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434